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KMID : 0367420040470121293
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Journal of Korean Pediatric Society
2004 Volume.47 No. 12 p.1293 ~ p.1299
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Cord blood Cytokines on the Development of Cerebral Palsy in Premature Infant.
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Kim Ki-Dae
Son Byeong-Hee
Oh Chang-Whan
Lee Jung-A
Kim Sung-Won
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Abstract
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Purpose : This study was performed to determine the relation between cord blood plasma cytokines responses and development of cerebral palsies in premature infants.
Methods : Interleukin-1β(IL-1β), Interleukin-6(IL-6), Tumor necrosis factor-α(TNF-α) were measured using ELISA kits in premature infants(n=60) who were admitted to St. Benedict Hospital from September 2001 to June 2003. Retrospective study was done by review of medical records.
Results : Cord blood levels of IL-1β, IL-6 and TNF-α in the cerebral palsy group were higher, especially IL-6 but were not significant, compared with the control group. Cord blood levels of IL-6 in the cerebral palsy without asphyxia, sepsis, PROM, RDS and pneumonia were significantly different, compared with the control group.
Conclusion : Cord blood levels of IL-1β, IL-6 and TNF-α in the cerebral palsy group were increased, but concentrations of IL-6 increased significantly. Cord blood levels of IL-6 may be a useful value to predict the development of cerebral palsy, because they are related to IL-6 rather than to TNF-α & IL-1β in this study. (Korean J Pediatr 2004;47:1293-1299)
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KEYWORD
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Cytokine, Interlukin(IL-1β, IL-6, TNF-α), Cerebral palsy, Premature
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